Drug-Related Hospitalizations at a Tertiary Level Hospital in Bangalore: A Prospective Study 736-740
Dr Raju Koneri, Professor of Pharmacology, KIMS Pharmacy College; Banashankari 2nd stage Bangalore 70 Phone- 09980006191; email@example.com
The Objective of the present study was to determine the causality, severity, preventability, classification of adverse drug events, and drug therapeutic failures resulting in hospitalization, at a tertiary level hospital in Bangalore. Prospective data was collected from a total of 155 consecutive adult patients hospitalized during a period of six months due to drug related events at the Kempegowda Institute of Medical Sciences, Bangalore. The prevalence of Drug-related hospitalizations was (6.4%)[95% CI 5.6%-7.7%] in the study. Multiple drug therapy in patients was associated with drug related hospitalizations. 50 % of the admissions were due to Adverse Drug Reactions (ADR), 38% due to Dose Related Therapeutic Failure (DTF), and only 12% were due to Self or Intentional Poisoning (SIP). On sub-group analysis, 64% of ADR were noted to be due to normal side effects; and 68% of DTF were due to non-compliance. Using Naranjoâ€™s probability scale for causality assessment, 58% of Drug Related Hospital Admission (DRHA) was classified as definite; whereas 36% was probable. Out of these, 84% of DRHA were predictable, whereas 16% were non-predictable. 72% of DRHA was managed by altering the dose. The prevalence of Drug-related hospitalizations is high in this hospital, which merits further research and intervention.