The Diagnostic And Prognostic Value Of Serum Adenosine Deaminase Levels In Head And Neck Cancer
Ashok Kumar. J., Professor and Head, Department of Biochemistry, Father Muller Medical College Kankanady, Mangalore 575002, Karnataka, INDIA.
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Serum adenosine deaminase (ADA) levels were estimated in 63 patients with histologically proven squamous cell carcinoma of the head and neck region of the body in different stages. Serum ADA levels were also estimated in 30 healthy controls. Serum ADA levels in cases (34.89 Â± 6.80 IU/L) was significantly increased when compared to the control group (20.47 Â± 3.33 I U/L). There was a highly significant correlation between the serum ADA level and the increasing disease stage (severity of the disease). The tumour status and metastasis of the tumour to the neck nodes has shown a correlation with serum ADA levels. After the treatment of head and neck cancers by different modalities, the serum ADA levels were found to be decreased (24.74 Â± 3.91) when compared to the serum ADA activity before treatment (34.89 Â± 6.80 IU/L).