Effects of Clinical, Haematological and Immunophenotyping Factors on the Prognosis of Acute Promyelocytic Leukaemia (APL) at the Tabriz Haematology and Oncology Research Centre
Iraj Asvadi Kermani MD, Hematology and Oncology Research Center, Tabriz University of Medical Sciences,Ghazi Tabatabai Hospital, Daneshgah Ave, PO Box: 5166614731 Tabriz/ IR Iran. Email address: email@example.com Tel/Fax: +98 0411 3343844
Background: Acute Promyelocytic Leukemia is one of AML subgroups that is high lighted by coagulopathy and different mode of treatment. It is specified by district cell morphology and immunophenotyping characteristics.
Aims: The aim of this study was evaluation of the effects of cytologic , clinical and biologic factors specially CD34 expression in prognosis in APL patients.
Materials and Methods: In a Descriptive retrospective analysis the files of 60 APL patients reviewed and the extracted data's statistically analyzed using SPSS soft ware with Chi Square and T- test.
Results:Dislike references complete remission and disease free survival (DFS) had no significant correlation with age, sex, WBC, Hb, platelet count, purpura, CD34 status, and percent of Blasts in bone marrow. There was no significantly statistical correlation between CD34 expression with morphology, age, sex, WBC, platelet count, percent of BM blasts and purpura. Cases with CD34 expression had sever anemia (5.8Â± 1.08) in comparison with CD34 negative APLs (P=0.020).
Conclusion:In spite of the influence of known prognostic factors on prognosis, results of our study were not concordant with references, therefore it is logical to think that in APL there should be different prognostic factors .Failure in obtaining complete remission in all CD34+APLs cases may be the cause of poor prognosis of CD34 positively in these patients and needs further studies for better clarification.