Evaluation Of Urinary Abnormalities In Urolithiasis Patients From “Kathmandu Region”
Dr. Arun Kumar MSc (Medical Biochemistry), PhD (Med) Assistant Professor, Department of Biochemistry Manipal College of Medical Sciences, Deep Heights 15, Post Box 155, Pokhara, Nepal, Email: email@example.com
We evaluated urinary abnormalities in 193 consecutive patients with renal stones, without any prior history, and compared them with age /sex matched healthy controls. Over a twenty four hour period, urinary oxalate, calcium, uric acid, struvite, cystine, sodium, magnesium, phosphorous and citrate were estimated. The urinary pH was also determined. In stone formers, the twenty four hour period evaluation levels of calcium (CI; 183.4–185.2), oxalate (CI; 43.4 – 43.8), uric acid (CI; 518.3-528.5) and sodium (CI; 230.9-232.1) excretion were significantly higher (p<0.001), as compared with controls. The twenty-hour urinary citrate (CI; 151.8–153.1), phosphate (CI: 241.7–245.7) and struvite (CI; 362.8–372.1) excretion was significantly lower than the control group (p<0.001). The cystine (CI; 454.3- 459.5) excretion in stone formers was significantly higher (p<0.05) as compared to the control group. The magnesium (CI; 123.1–124.3) excretion was lower in stone formers as compared to controls, and was significant (p<0.01). The pH of urinary stone formers was 5.13 ± 0.034, whereas in controls, it was 6.54 ± 0.045 (p< 0.001). Hypocitraturia is the main cause of renal calculi, along with hypomagnesuria and hypophosphaturia in the patients of Kathmandu region. On the basis of urinary abnormalities, further stone formation in the patient can be prevented by dietary modifications.