Results Of Two Multicentric, Comparative, Randomized, Parallel Group Clinical Trials To Evaluate The Efficacy And Safety Of Dexketoprofen Trometamol In The Treatment Of Dental Pain And Dysmenorrhoea In Indian Patients
1086-1091
Correspondence
Dr. Balani M. M.A.Rangoonwala College
of Dental Sciences & Research Centre,
2390-B,K.B.Hidayatullahroad, Azam Campus,Corresponding Author
Camp,Pune-411001.
Ph:9422555576,Email:drmanojbalani@gmail.com
Background: Dexketoprofen is the active enantiomer of the popular NSAID Ketoprofen which is a 50:50 mixture of S (+) and R (-) enantiomers.
Aims: To demonstrate therapeutic efficacy and safety of Dexketoprofen 25 mg as compared to Ketoprofen 50 mg in patients undergoing dental surgery and in patients with dysmenorrhoea.
Study Design: Multicentric, comparative, randomized, parallel group studies. Materials and Methods: Out patients undergoing third molar extraction were randomized to receive either Dexketoprofen or Ketoprofen. In a separate study, patients with dysmenorrhoea were randomized into similar two groups. Pain intensity as recorded on Visual Analogue Scale before therapy and at regular intervals after therapy was quantified and statistically analysed.
Materials and Methods: Out patients undergoing third molar extraction were randomized to receive either Dexketoprofen or Ketoprofen. In a separate study, patients with dysmenorrhoea were randomized into similar two groups. Pain intensity as recorded on Visual Analogue Scale before therapy and at regular intervals after therapy was quantified and statistically analysed.
Results: In both the studies, the groups were comparable in demographics and baseline pain intensity. Dexketoprofen was as effective as Ketoprofen in relieving pain during menstruation. In case of dental pain, Dexketoprofen provided early onset of statistically significant analgesia as compared to Ketoprofen.
Conclusions: Dexketoprofen (25mg) is as effective as Ketoprofen (50mg) in the treatment of dysmenorrhoea and is a faster and equally safe analgesic in the treatment of acute pain of dental surgery.