Evaluation Of Effects Of Laparoscopic Surgery On Hepatic Function 1155-1162
Dr.Tauro LF,Dept.of General SurgeryFr. MullerMedicalCollegeHospitalKankanady,Mangaloreâ€“575002(D.K.)Karnataka,INDIA)Ph.No:Hosp:(0824)2436301,Res:(0824) 2224911,E-Mail:firstname.lastname@example.org
Aim:The purpose of this study was to investigate the effect of laparoscopic surgery on liver function and the possible mechanisms behind such effect.
Methods:Blood samples were collected from 60 patients undergoing various types of laparoscopic procedures, preoperatively once and post operatively on day 1 and day 7. They were tested for liver function by comparing the levels of serum bilirubin, serum alanine amino transferase (ALT), serum aspartate aminotransferase (AST) and serum alkaline phosphatase. The time of CO2 insufflation was also measured.
Results:The levels of serum AST, ALT, bilirubin and alkaline phosphatase increased significantly during the first 48 hrs post operatively. Doubling of pre-op values of AST was seen in 33.3% and of ALT was seen in 31.7%. By 7th post operative day, the levels of AST, ALT, bilirubin and alkaline phosphatase returned to near pre-operative values. CO2 pneumoperitonium was found to be a major cause of increased liver enzymes and serum bilirubin in the study.
Conclusion:Transient elevation of hepatic enzymes occurs after laparoscopic surgery and CO2 pneumoperitoneum seemed to be the major reason.