Serum Lipid Peroxidation And Leptin Levels In Male And Female Type 2 Diabetic Patients In Gorgan (South East Of Caspian Sea), Iran 1903-1910
Abdoljalal Marjani,Gorgan Faculty of Medicine,Department of Biochemistry and Biophysics,Biochemistry and Metabolic Disorder Research Center, Golestan University of Medical Sciences,Gorgan, Golestan province,.Iran.Tel & Fax: +98(171)4421651 & 4440225 E.mail:email@example.com
Background: The aim of the present study was to determinate the possible relationship between serum leptin and lipid peroxidation in male and female type 2 diabetic patients in Gorgan, Iran.
Methods: The subjects consisted of fifty type 2 diabetic patients and fifty age and sex-matched control subjects. The concentration of leptin, malondialdehyde, lipid parameters and insulin were measured in all subjects. The results were evaluated by using Independent sample â€˜tâ€™ test and Spearmanâ€™s correlation coefficient test.
Results: Leptin was correlated with BMI (male: r=0.339 and female: r=0.426, p<0.05) and malondialdehyde levels (male: r=0.124 and female: r=0.271, p<0.05) in the type-2 diabetic patients. In the control subjects, only a correlation between leptin and BMI was found (male: r=0.165, female: r= 0.037, p<0.05).
Conclusions: In the correlation analysis using leptin as the dependent variable, BMI was found to be the predictor of leptin in males and females. Increased lipid peroxidation and hyperleptinaemia may play a role in the beginning and development of type 2 diabetes mellitus in this area.