
Expression Of P53, Ck7, Ck20 And Rb Proteins in Oesophageal Squamous Cell Carcinoma In Iran
2459-2462
Correspondence
Seyed Mohammad Mohseni Mehran (DVM,PhD)
Department of Physiology,Rasht Medical School Guilan University of Medical Sciences,Rasht, (Iran)Tel:+981316690099
,Fax: +981316690007,Email: mohsenimehran@gums.ac.ir
Background
Cancer of the oesophagous is one of the most malignant tumours and has a poor prognosis. The p53 and retinoblastoma (Rb) genes are involved in the regulation of the cell population by the suppression of cell proliferation. Our aim was to show whether the expression of the p53, Ck7, Ck20 and Rb genes could be used as a prognostic indicator in oesophageal squamous cell carcinoma.
Methods
Samples obtained from 49 patients undergoing subtotal or total oesophagectomy were mmunohistochemically stained for studying the expression of the p53, Ck7, Ck20 and Rb genes and then the clinicopathological characteristics of those patients were investigated.
Results
P53 was positive in 40.4% of the patients (more than 20% of the tumour cells were stained), 12.8% were partially positive and in others, it was negative. Immunohistochemical staining for the expression of the Ck7, Ck20 and Rb genes in our samples was negative. P53 seemed to have significance in the prognosis of the cancer but Ck7, Ck20 and Rb expression did not have prognostic significance in the surgical treatment of oesophageal cancer.