Variations Of Lipid Peroxidation And Superoxide Dismutase Activity Due To Haemodialysis In Gorgan 2763-2767
Mohammad Moujerloo,Golestan University of Medical Sciences, Department of Endocrinology, Gorgan, (IRAN) E-mail : firstname.lastname@example.org , Tel & Fax: +98(171)4421651 & 4440225
Background: Free radicals are formed in all living organisms during normal cell metabolism. Patients with chronic renal failure who are regularly dialyzed are candidates for free radical damage. The aim of this study was to evaluate the variations of lipid peroxidation and erythrocyte superoxide dismutase due to haemodialysis in Gorgan.
Method: The sampling procedure was the purposive sampling of22 patients (age 43.54±9.21 years of old ) with chronic renal failure (CRF) disease who were haemodialysed at the 5th Azar hospital of the Gorgan dialysis center (from September 2007 to February 2008) and 22 age and sex matched healthy controls (43.77±9.33 years of old ) were recruited for this study. This study was a clinical trial.
Results: Plasma lipid peroxidation levels showed significant differences between the predialysis and the control group (P<0.001). They were found to be increased in the post-dialysis group when compared with the predialysis and the control groups(P<0.001).Erythrocyte superoxide dismutase levels were found to be decreased in the post-dialysis group when compared with the predialysis and the control groups (P<0.001).There was also significant difference between it’s levels in the control and the predialysis groups (P<0.001).Erythrocyte superoxide dismutase levels were lower in the dialysis group than in the control group. (P<0.001).
Conclusions: The significant differences of the erythrocyte superoxide dismutase levels between the pre- and post-dialysis groups may be related to the loss of this antioxidant through membranes during the dialysis process and the decreased superoxide dismutase levels may also be related to the increase of lipid peroxidation in haemodialysed patients. This situation may play an important role in the development of atherosclerosis in these groups.