Comparative Study Of Oxidative Stress And Antioxidant Activity In Males And Females With Increase In Age 2771-2775
*Asst Professor Department of Physiology, Adesh Institute of Medical Sciences and Research,Bathinda-151101, Punjab,[India] E-mail email@example.com. Tel: +91-9876010729
Aim:The aim of the study was to compare the extent of free radical damage in the form of oxidative stress and the antioxidant activity with increase in age in healthy males and females.
Methods: The present study was conducted in 150 normal healthy subjects of both sexes in the age ranging from 15 â€“ 65 years. They were divided in 3 groups. Each group had equal number of male and female subjects. Oxidative stress was by measured by estimating malondialdehyde [MDA], a lipid peroxidation product, and antioxidants in the form of superoxide dismutase [SOD] and glutathione peroxidase [GPX] in both male and female subjects of all age groups.
Results: MDA levels increased significantly with increase in age of all subjects and this increase was more in females was more than males of each group. Levels of antioxidant enzymes [SOD and GPX] decreased with increase in age more in males than females of each group.
Conclusion: Males are exposed to greater risk of oxidative stress with age compared to females which may be related to lower life expectancy in males.