Maternal And Neonatal Serum Magnesium Concentrations In Neural Tube Defects Pregnancies In Gorgan (North Of Iran) - A Case Control Study 2817-2821
Mohammad Jafar Golalipour
Gorgan Congenital Malformation Research Center, Gorgan University of Medical Sciences.
P.O. Box: 49175-553.
Phone & Fax: + 98(171)4425165, 4425660
Objective: Neural tube defects (NTD) comprise a group of congenital malformations that include spinabifida, anencephaly and encephalocele. Previous studies have reported the embryotoxic and teratogenic effects of Magnesium deficiency in animal models. Therefore, this study was conducted to determine an association between Magnesium deficiency and neural tube defects in Northern Iran, which was reported to have a high prevalence of neural tube defects.
Methods: This hospital based case control study was conducted on 13 mothers with newborns having neural tube defects and 35 healthy mothers as controls in Northern Iran during 2005-2006. Serum Magnesium was measured by spectrophotometery.
Results: Serum Magnesium levels in mothers with NTD affected newborns and in mothers with healthy newborns were 1.5±0.6 and 1.32±0.3 micromol/litter, respectively. Overall, 46.2% mothers in the case group and 48.6 % mothers in the control group had Magnesium deficiency. Logistic regression analysis showed no association between the presence of NTD and Magnesium deficiency (OR =0.9, 95% Cl: 0.2-3.9, p=0.88).
Serum Magnesium levels in newborns with NTD and healthy normal newborns were 1.4±0.6 micromol/litter and 1.3±0.4 micromol/litter, respectively. Overall, 30.8% newborns in the case group and 37.1 % newborns in the control group had Magnesium deficiency. Logistic regression analysis showed no association between the presence of NTD and Magnesium deficiency (OR =0.8, 95% Cl: 0.1-3.4 p=0.68).
Conclusion: The present study did not find any association between the occurrence of NTD and Magnesium deficiency.