Antimicrobial Sensitivity Pattern Among Organisms Which Were Isolated From The Endotracheal Aspirates Of Patients With Ventilator Associated Pneumonia
Dr Peter George MD, Department of Medicine,
Yenepoya Medical College, University Road,
Mangalore, Karnataka State, India.575018.
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Ventilator associated Pneumonia (VAP) is seen in 9 to 27% of all endo-trachealy intubated patients.
Aim and objectives: To study antimicrobial sensitivity among organisms isolated from endo-tracheal (ET) aspirates of patients with VAP.
Materials and methods: This retrospective study is designed to collect with data from medical records of patients admitted to the ICU of a tertiary referral hospital in the previous calendar year. 50 cases with VAP admitted to ICU were randomly selected and assessed for their clinical parameters (history and clinical examination) and investigations.
Results: ET aspirate culture and sensitivity sampling done in 50 subjects, only 32 samples yielded significant growth. Acinetobacter were isolated in 37.5%(12), Pseudomonas in 21.87%(7), Klebsiella in 15.6%(5), Enterobacter in 12.5%(4), Citrobacter in 6.25%(2 )and Staphylococcus in 6.25%(2 ). Acinetobacter were sensitive to Amikacin (44.66 %), Gatifloxacin & Imipenem (33.33%), Meropenem &Cefaperazone (25 %). Pseudomonas were sensitive to Amikacin, Pipercillin, Cefaperazone (85.71%), Ceftriaxone (71.42 %), Imipenem, Meropenem and Gatifloxacin (57.14 %).
Conclusion: The commonest organism isolated ET aspirate cultures were Acinetobacter, as seen in similar Indian studies. The infections can be reduced by practicing aseptic measures in ICU. The overall outcome of VAP varies with the antibiotic policies of individual centers.