Histochemical Study Of Salivary Mucins In Normal And Neoplastic Salivary Glands
*DEPARTMENT OF ORAL AND MAXILLOFACIAL PATHOLOGY, SRI SAI COLLEGE DENTAL SURGERY, HYDERABAD, INDIA, E-MAIL: firstname.lastname@example.org, FAX: +918416253998, PHONE: +91 9885864376; **DEPARTMENT OF ORALMAXILLOFACIAL PATHOLOGY, G. PULLA REDDY COLLEGE OF DENTAL SCIENCES, KURNOOL, INDIA, E-MAIL:email@example.com, PHONE: +91 9448457595
Salivary glands include major and minor salivary glands which are important components of the oral cavity and theirsecretions directly bathe the tissues. The biochemical and histochemical analysis of saliva revealed the presence of mucins as the main component, which showed sugar moieties and amino acids. The histochemical properties of mucins show the presence of glycoproteins andproteoglycans which differ in their chemical and structural natures. Mucins are altered in their normal and pathological states. Using special stains like Periodic Acid Schiff Reagent [PAS], Alcian Blue [AB], Aldehyde Fuchsin [AF], Mucicarmine [MC] they can be categorized into acidic, neutral, sulpho and sialomucins.
The present study was carried out to assess different staining patterns of mucins in normal salivary glands and their neoplastic counterparts, to interpret type of mucin and change in their expression in normal and neoplastic counterparts.
Methods and Materials:
The study comprised of 19 salivary gland neoplasms which include 9 pleomorphic adenoma [PA], 4 adenoid cystic carcinoma [ADCC] and 6 mucoepidermoid carcinoma[MEC] and 10 normal salivary glands[1 parotid, 7 sub mandibular, 2 sub lingual] which were analyzed with special stains.
The results showed varied heterogeneity of mucin expression in mucous acini and change in mucin expression from benign to malignancy.
Summary and Conclusion:
The study concluded in considering the probable role of mucins in tumorigenesis and also its usage as an adjunct to diagnosis.