The Role of Biochemical Markers in the
Prediction of Microvascular Complications
in Type-2 Diabetes Mellitus
V. Siva Prabodh, Associate Professor
Department of Biochemistry
NRI Medical College
Guntur (Dist) Pin code - 522503
Andhra Pradesh, India.
The microvasular complications of diabetes encompass longterm complications which affect the small blood vessels. These classically have included retinopathy, neuropathy and nephropathy. The biochemical parameters play a key role in the prediction of microvascular complications in diabetes mellitus. Therefore, the present study was undertaken to investigate the role of biochemical markers in the prediction of microvascular complications in patients with type 2 diabetes mellitus. Fifty type 2 diabetes mellitus patients were studied for their fasting blood sugar, glycosylated haemoglobin, serum creatinine, blood urea nitrogen, lipid profile and microalbuminuria levels and they were also tested for the presence or absence of microvascular complications. The analysis was categorized, based on the presence or absence of the microvascular complications. Thirty non diabetic, healthy subjects were chosen as the control group.
The analysis showed that thirty six subjects had microvascular complications. The incidence and the progression of the microvascular complications increased with hyperglycaemia, a longer duration of diabetes, dyslipidaemia and the presence of microalbuminuria levels in patients with type 2 diabetes mellitus. Therefore, poor glycaemic control, a longer duration of diabetes, dyslipidaemia and the progression of microalbuminuria can predict the microvascular complications in patients with type 2 diabetes mellitus.