(a), Uric Acid, Oxidants
and Antioxidant Vitamins in Type 2 Diabetic
Patients without Cardiovascular Complications
Professor & Head of Department of Biochemistry
Sri Venkaterswara Institute of Medical Sciences (Svims)
Tirupati-517507, Chittor (District)
Andrapradesh, India, Ph: +91 9493547663
Introduction: Type 2 diabetes mellitus patients have increased morbidity and mortality as compared to the general population, particularly with respect to coronary heart disease (CHD), possibly due to increased oxidative stress and dyslipidaemia, and recent data suggest that elevated levels of lipoprotein (Lp) (a) and uric acid (UA).
Methods: The present study included 60 type 2 diabetic patients without any cardiovascular complications and 60 age and sex matched healthy subjects as the controls. The serum levels of lipids, lipoproteins, lipoprotein (a), oxidants and antioxidant vitamins in the type 2 diabetic patients and in the healthy controls were estimated.
Results: The Lp (a), UA, lipid peroxide (LPO), total cholesterol, triglyceride and low-density lipoprotein cholesterol (LDL-C) levels were significantly elevated, while the vitamin C and E levels were significantly lowered in the diabetic patients as compared to those in the controls (p<0.05). In the correlation analysis, lipid peroxide was found to be negatively correlated with vitamin C and E (r = 0.52, p=0.0010, r = -0.49, p=0.0019) and to be positively correlated with uric acid (r = +0.31, p=0.0246) in the diabetic patients. In the ROC curve analysis, significant areas under the curve (AUC) were obtained for lipoprotein (a) (p<0.01), uric acid (p<0.05) and lipid peroxide (p<0.05).
Conclusion: The study showed significantly elevated Lp (a) and uric acid levels in the type 2 diabetic patients without any vascular complications, thus indicating that their measurement, along with the other routine investigations in the type 2 diabetics, may facilitate the early identification and the interventions for patients who were prone to cardiovascular complications.