TNF- α is An Inflammatory Marker of
Cardiovascular Risks in
Non-Alcoholic Fatty Liver Disease
S.F. Haque, MD (Med.), Ph.D. (Med.)
Department of Medicine, JN Medical College,
Aligarh Muslim University, Aligarh
Phone : 09412517518
E-mail : email@example.com
Non-alcoholic fatty liver disease (NAFLD) is a common clinical condition with histological features resembling those of alcohol induced liver injury but occurs in patients who do not abuse alcohol. It is often associated with features of obesity, hypertension, dyslipidemia and type2 diabetes mellitus. NAFLD plays a central role in the pathway connecting the metabolic syndrome and cardiovascular disease.Overall, the current body of evidence strongly suggests that NAFLD is likely to be associated with increased cardiovascular disease risk, and raises the possibility that NAFLD may be not only a marker but also an early mediator of atherosclerosis.
Aims of the present study: Our study was an attempt to analyze the association between non-alcoholic fatty liver disease, and various cardiovascular risk factors & plasma biomarkers of inflammation like TNF-α in non-alcoholic subjects.
Methods: In this prospective, open label, observational study, 39 cases of non-alcoholic fatty liver diseasewere evaluated for inflammatory markers and cardiovascular risk factors. The data was analysed and the results were given in percentage in accordance with previous related studies.
Results: In patients of non-alcoholic fatty liver disease serum levels of inflammatory marker TNF-α are significantly elevated, supporting the view that inflammation plays an important role in the pathogenesis of NAFLD.
Conclusion: The study concludes that there is significant association of inflammatory markers and cardiovascular risk factors in patients of non-alcoholic fatty liver disease.