Immune Mediated Containment And The Consequences Of The Human Immunodeficiency Virus Infection 131-133
Dr Srinivas R Deshpande
Professor and HOD Biochemistry,
Malabar Medical College, Modakallur, Atholi, Calicut Dist, Kerala 670001
The Human immunodeficiency virus infection is essentially an infection of the immune system, with progressive and profound defects in the cell mediated immune response. The pathogenesis of the Human immunodeficiency virus infection is a multi-factorial process, consisting of aberrant cellular activation and the disregulation of nearly every aspect of the immune system. The lentivirus subverts the immune system by infecting the CD4+Tcells that normally orchestrate immune responses and by activating the immune system and inducing a cytokine milieu that the virus uses to its own replication advantage. The disease outcome depends on the innate immune response, the adaptive immune response, the host genetic factors and the differences in viral pathogenicity.