Evaluation of Serum Selenium Level in Patients
With Uncomplicated Diabetes Mellitus, Raipur, India
Dr Presenjit Daulat Raut (09039267377)
Asst. Prof. (Pharmacology)
Pt.JNM Medical College, Raipur, CG-492001 India
Objective-Free radicals have important role in the pathogenesis of diabetes mellitus. In diabetes, free radical production is increased whereas capacity of antioxidant system is reduced. This study was, therefore designed to determine and evaluate the serum selenium level in patient with uncomplicated diabetes mellitus and a control group of non-diabetic individuals.
Study design- Hospital based non randomized, multistage, stratified, cross-sectional comparative study.
Material and Method- 50 uncomplicated diabetic patients (23 male, 27 female) with mean age of 49.10Â±6.48 years were enrolled in the study. Control group was composed of 50 healthy individual (22 male, 28 female) with mean age of 52.74 Â±7.5 years. Serum selenium level was determined by using Hydride generation atomic absorption spectrometry in diabetic patients and controls.
Result â€“ Mean serum- selenium concentration measured in uncomplicated diabetic patients (51.9Â±8.23 Âµg/lit) were significantly lower than those determined in control group (130.66Â±37.18 Âµg/lit) (p< 0.05).There was significant decrease in mean serum selenium level with increasing age. (p<0.05).No significant differences in serum selenium levels were found in relation to the sex of the patient (p> 0.05).
Conclusion- The result of this comparative evaluation confirms the relation between low serum selenium and diabetes. Significant reduction in selenium levels are indicators of metabolic response to oxidative stress in patient with diabetes. Hence, selenium can be used in diabetic patient to prevent the late complications.
The present study indicates that since it is a hospital based study, the same study should be conducted in general population (community based) to further evaluate the effect of serum-selenium in diabetes.