Diabetes and Oral Changes: The Tryptophan Metabolism Link?
517-520
Correspondence
Rishabh Kapila
House Number 110, Sector 12-A
Panchkula, Haryana - 134109, India.
Phone: +91-925663774
E-mail: rishabh_kapila@rediffmail.com
Objectives: The objective of this study is to determine whether the severity of periodontal disease is associated with an increase in the levels of tryptophan and its metabolites in the saliva of type 2 diabetic patients.
Materials and Methods: 40 subjects were selected for this study. Each subject of the study was subjected to a detailed case history and intraoral examination. Then, the glycosylated haemoglobin estimation, the CPI scoring and the assessment of the salivary tryptophan levels and the levels of its metabolite were done. The data which was obtained was subjected to statistical analysis.
Results: The mean salivary tryptophan metabolites were higher in diabetic individuals than non-diabetic individuals. An increase in the CPI score was associated with an increase in the levels of the salivary tryptophan metabolites.
Conclusion: A relationship exists between the severity of periodontal disease and the levels of salivary tryptophan and its metabolites in type 2 diabetic individuals. This study may add an insight into an alternate pathway for the development of periodontal disease in the type 2 Diabetes mellitus individuals and kynurenergic agents, which may act as new treatment modalities for such cases.