
Uric Acid in Relation to Type 2 Diabetes Mellitus Associated with Hypertension
1140-1143
Correspondence
Dr. Shabana S,
Associate Professor, Department of Biochemistry,
Dr. Pinnamaneni Siddhartha Institute of Medical Sciences
and Research Foundation, Chinna Avutapalli - 521286,
Gannavaram Mdl, Krishna Dt, A.P. India.
Phone: +919848310952
E-mail: shabanashireen2000@yahoo.com
Introduction: The role of uric acid in the progression of prediabetes to diabetes has been known. However, conflicting data exist as regards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors and complications.
Objective: The present study was designed to look for any association of serum uric acid with hypertension in type 2 diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data.
Material and methods: Fifty patients with type 2 diabetes mellitus and 50 healthy controls were included in this study. They were further divided into different groups, based on the sex, the duration of diabetes, and the diabetes which was complicated with hypertension.
Results: The circulatory levels of glucose, total cholesterol and triglycerides were found to be elevated in the diabetics of either sex as compared to those in the controls. There was no significant difference in the serum uric acid levels between the diabetics and the non-diabetics, either in males or females. A negative correlation was observed between the fasting plasma glucose and the serum uric acid levels in both male [r = −0.60] and female [r = −0.60] diabetic patients. The serum uric acid levels marginally decreased with an increased duration of diabetes. The hypertensive male and female diabetics were found to have significantly decreased (P < 0.05) serum uric acid levels as compared to the corresponding non-hypertensive diabetics.
Conclusion: It was concluded from the present study that there occurs a significant decrease in the serum uric acid levels in hypertensive diabetics (both in males and females) in comparison with the non-hypertensive diabetics.