Urinary Tract Infections – An overview on the Prevalence and the Anti–biogram of Gram Negative Uropathogens in A Tertiary Care Centre in North Kerala,India
Dr. Syed Mustaq Ahmed
Associate Professor, Department of Microbiology
MES Medical College,Perinthalmanna, dist
Malappuram, Kerala 679338, India.
Despite the advances in the antimicrobial therapy, Urinary Tract Infections (UTIs) tends to remain a major health hazard, which are responsible for significant morbidity, often resulting in alarming complications. A variety of organisms have been implicated in its aetiology. The indiscriminate and the inappropriate usage of anti-microbial agents has led to the emergence of resistant strains.
To determine the prevalence and the antimicrobial sensitivity pattern of uropathogens.
Methods and Materials:
The urine samples from the patients at a medical college hospital , were processed according to the standard protocol over a period of one year from April 2011 to March 2012. The antimicrobial susceptibility was tested by the modified Kirby-Bauerâ€™s disc diffusion method as per the CLSI guidelines. The data was interpreted by using the WHO Net Antibiotic Susceptibility Surveillance Software.
Out of 2540 urine samples, 511(20.12%) were found to be positive for microbial isolates, of which 343 samples (67.12%) were from females and 168 samples (32.36%) were from males. The highest rate of the isolation was detected in the geriatric age group i.e., 61-80 years (39.53 %). The most isolated organism was Escherichia coli (81.80%). The isolation rates were highest in the surgical departments (38.34%). Piperacillin/tazobactam, cefoperazone/sulbactam, imipenem and amikacin were found to be the most effective drugs among a majority of the isolates.
Before prescribing the antimicrobial therapy, a thorough knowledge of the susceptibility patterns of the uropathogens is essential to avoid incongruous and irrational antibacterial usage and to restrain the further development of drug resistance.