A Study on the Mast Cells in Appendicitis
Dr. Sulochana Sonti,
Assistant Professor, Department of Pathology,
Saveetha medical college, thandalam, Chennai,
Aim and objective: To study the number and distribution of mast cells in surgically resected appendices of normal and inflamed, age and sex wise. Introduction: Mast cells play an important role in various inflammatory and immune reactions. The association of changes in the number of mast cells in appendicitis is unclear. Mast cells could be one of the important cell populations responsible for nerve proliferation and hypertrophy in cases with clinically and histo pathologically diagnosed appendicitis.
Materials and Methods: Two ninety appendicitis cases were analyzed with routine hematoxyline and eosine staining and also other special stains like toluidine blue ,giemsa and leishmains stain were used. The number of mast cells present in ten consecutive high power field was counted by randomly in all the sections with one percent toluidine blue and graded the mast cells.
Results: Among two ninety cases , the acute appendicitis were one fifty eight cases (158), with higher mast cell count and chronic appendicitis were one hundred four cases(104), wit highest mast cell count and normal appendices were twenty eight cases , did not show any significant variation in mast cell count.
Conclusion: We concluded that mast cell count was higher in acute appendicitis indicating immunological and non immunological injury causing acute appendicitis. The mast cell count was highest in chronic appendicitis, indicating growth interaction between mast cells, nerves and fibrosis.