The Immunohistochemical Expression of the Oestrogen Receptor (ER), HER-2/ne u and Cytokeratin 8/18 and 5/6 in Invasive Breast Carcinoma 1495-1498
Dr. Bharti Rattan
372 Sec 12, Panchkula Haryana-134112 (India).
An immunohistochemical study was done on 39 cases of invasive breast carcinoma for further sub-classification, for predicting their prognosis and therapeutic approaches. These cases were evaluated for the expression of cytokeratin Ck 8/18, ER and Her-2/neu and 28 cases were subjected to the evaluation of cytokeratin Ck 5/6, which especially included the cases which were negative for all the three markers. ER was positive in 7 cases, with Her-2/neu being positive in 8 cases and cytokeratin 8/18 being positive in 33 cases. Cytokeratin 5/6 was positive in 7 cases, with 4 cases showing Ck 5/6 and Ck8/18 positivity, 3 cases showing positivity for Ck 5/6 only and 3cases showing negativity for all the 4 markers. Thus they were classified as the luminal A, luminal B, combined, basal and the null types respectively.