Nimesulide Induced Histopathological Changes in The Vas Deferens of Mice 2116-2118
Dr. Thotakura Balaji,
Professor, Department of Anatomy,
Chettinad Hospital and Research Institute, Kelambakam â€“ 603 103, Tamil nadu, India.
Phone: 9492776417, E-mail: email@example.com
Aim: Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty.
Aims and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract.
Material and Methods: Nimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice. Results: The vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer.
Conclusion: Nimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.