Incresed Non-Enzymatic Glycation of Plasma Proteins and Hemoglobin in Non-Diabetic Patients with Acute Myocardial Infarction (MI) 2692-2693
Dr. Medha Rajappa,
Assistant Professor, Department of Biochemistry,
Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry-605 006, India.
Phone: 09486398875, E-mail: email@example.com
Background: Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute Myocardial Infarction (MI) patients.
Methods: Eighteen acute Myocardial Infarction (MI) patients and 20 healthy controls were enrolled for the present study. Fasting plasma glucose, fructosamine, glycated hemoglobin were evaluated.
Results: A significant rise in the mean values of fructosamine and glycated hemoglobin was found in acute myocardial patients when compared with controls. When Pearsonâ€™s correlation analysis was performed, no significant correlation was found between fasting plasma glucose with either fructosamine or glycated hemoglobin levels.
Conclusion: This data suggests an increased glycation of both plasma proteins and glycated hemoglobin in acute myocardial patients, which might be independent of prevailing glucose concentration.