Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with
46, XX Karyotype: A Case Report
Dr. Deepa V. Kanagal,
No. 104, Dune Apartments, Kadri, Shivbagh, Mangalore, Karnataka, India.
Phone: 09980164615, E-mail: email@example.com
Gonadoblastoma is a rare gonadal tumour consisting of a mixture of germ cells and sex cord stromal derivatives resembling immature granulosa and Sertoli cells. It usually arises in various types of gonadal dysgenesis containing Y chromosome like pure or mixed gonadal dysgenesis. Occurrence in phenotypically and chromosomally normal women is very rare. We report here a case of gonadoblastoma with dysgerminoma in a 14â€“yearsâ€“old girl who presented with a huge tumour, virilisation and normal 46XX karyotype. Association of dysgerminoma is seen in 50% cases of gonadoblastomas. Elevated tumour markers like hCG and alpha Fetoprotein may make the diagnosis challenging.