Effect of Periodontal Therapy on Salivary Interleukin-12 Levels in Chronic Periodontitis ZC90-ZC92
Dr. Anamika Sharma,
Professor and Head, Department of Periodontology,
Subharti Dental College and Hospital, Delhi-Haridwar by Pass Road, Subharti Puram, Meerut, U.P., India.
Phone : 09219600994, Fax : 0121-2439067/3058030, E-mail : firstname.lastname@example.org
Background: Interleukin-12 (IL-12) is considered a central regulator of host resistance against a variety of pathogens. The influence of scaling and root planing was evaluated on amount of IL-12 in salivary fluid of patients with chronic generalized severe periodontitis, in relation to clinical parameters.
Materials and Methods: A total of 50 subjects were enrolled, of which 25 had chronic generalized severe periodontitis, and 25 periodontally healthy as control. The clinical parameters included plaque index (PI), gingival index (GI), pocket probing depth (PPD) bleeding on probing (BOP) and clinical attachment loss (CAL). The level of IL-12 in salivary fluid was measured by ELISA kit at baseline and at four week following scaling and root planing.
Results: Mean IL-12 levels in patients with periodontitis at baseline (9.79 ± 5.70 pg/ml) were higher than in controls (9.18±4.94 pg/ml; p=0.54. ) Scaling and root planing resulted in significant increase in IL-12 levels (mean: 15.93±12.09 pg/ ml; p =0.001) (control vs postoperative p <0.001). No significant correlations were found between IL-12 levels and any of the above clinical parameters.
Conclusion: Short-term nonsurgical therapy resulted in a significant improvement in periodontal indices and a marked increase in IL-12 levels