A Rare Case Report of Clear
Cell Variant of Oral Squamous
Cell Carcinoma
QD07-QD09
Correspondence
Dr. Harkanwal Preet Singh,
Senior Lecturer, Department of Oral Pathology, Dasmesh Institute of Research and Dental Sciences,
Faridkot, Punjab, India.
Phone: 9501544877, E mail: hkps0320@yahoo.com
Clear cell squamous cell carcinoma (SCC) is an extremely rare heterogenous group of malignant tumour with incompletely understood aetiology. We, hereby present a case of clear cell variant of squamous carcinoma on buccal mucosa in 52-year-old male patient. Histopathology showed sheets of squamous cells with clear cell differentiation and malignant features. Histochemical findings showed negative staining for Periodic Acid-Schiff (PAS), mucicarmine and Oil Red O. Immunohistochemical investigations revealed positive staining for CK 8-18 and negative for S-100. We conclude by emphasizing on the need of careful analysis of all the histopathological and IHC investigations. To predict the exact prognosis of this rare variant more number of case reports are expected to be published in future.