A Portal for the Oral Diagnostician
Dr. Annette Milton B.,
(Oral Medicine and Radiology)
HIG 443,E/7,Bhopal, Madhya Pradesh, India.
Phone: +919826088574, Email id: email@example.com
Background:Depressive disorders, worldwide, may rank second by the year 2020. In India; about 10 million people suffer from depressive disorders, the prevalence rate being recorded as 31.2 for every 1000 individuals. A significant impairment of all personal hygiene may occur due to a depressive episode which in turn may result in altered biochemical composition of some important salivary parameters. The present study was done to assess the relationship and bring about a comparison of certain selective sialochemical alterations between normal and subjects with depressive disorders.
Settings and Design: The present study was a hospital- based clinical cross-sectional study which was conducted in Bhopal, the heart of Madhya Pradesh, India. The survey period extended over a period of one year and two months, from May 2009 to July 2010.
Material and Methods: Unstimulated whole saliva was analysed biochemically for a - amylase, calcium, sodium, potassium, total proteins and urea. The data obtained in this study were statistically analyzed by using Unpaired Studentâ€™s tâ€“test.
Results: Salivary calcium and total protein levels were found to be statistically significant among all three groups (p< 0.0001). Salivary amylase levels between Groups II and III and between Groups I and III (p< 0.0001) was statistically significant while the salivary urea levels between Groups I and Group II and between Groups I and III were found to be statistically significant (p< 0.0001). However, there was no statistical difference in their sodium and potassium levels.
Conclusions: It was observed that drugs do affect the salivary composition. It was observed that cyclic antidepressants pro - duced significant alteration in the sialochemical constituents of saliva as compared to TCAs and TeCAs.