Angiotensin II Levels in Gingival Tissues from Healthy Individuals, Patients with Nifedipine Induced Gingival Overgrowth and Non Responders on Nifedipine ZC92-ZC94
Dr. Suresh Ranga Rao,
Professor and Head, Department of Periodontology, Faculty of Dental Sciences,
Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, India.
Context: The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine.
Aim: This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth.
Materials and Methods: Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit.
Results: Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01).
Conclusion: The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth.