A Prediction Formula for Double Product in Pregnancy CC20-CC22
Dr. Anita Teli,
Assistant Professor, Department of Physiology, KLE Universityâ€™s Jawaharlal Nehru Medical College,
Belagavi â€“ 590010, Karnataka, India.
Introduction: Maternal cardiovascular changes in pregnancy are numerous and increase in double product throughout pregnancy is the part of the same process. Double product is a cardinal surrogate of the myocardial oxygen demand and cardiac workload. It is the product of heart rate and systolic blood pressure and an important determinant of cardiovascular risk in hypertensive patients.
Aim: This study was intended to determine the double product by comparing normal individuals with different trimesters of pregnancy.
Materials and Methods: A cross sectional study was conducted in 220 healthy women in the age range of 18-35 years with 60 subjects each in 1st, 2nd and 3rd trimesters and 40 non pregnant subjects as control group. Cardiovascular parameters were recorded in both the groups. Statistical analysis was done by comparison of parameters using one-way ANOVA and post-hoc by Tukey-Krammer test. Correlation of double product and weeks of pregnancy was done using Pearsonâ€™s correlation. Regression analysis was done to know the predictor of double product.
Results: It was observed that there was statistically very highly significant increase (p=0.000) in the double product throughout the pregnancy and duration of pregnancy was found to be the predictor of the product.
Conclusion: The increase in the double product is due to increase in heart rate and stroke volume. Double product is the useful predictor for early identification of preeclampsia and acute myocardial infarction in pregnant women when compared to normal non- pregnant women and hence helps in the early management of complications.