Cortical Clefts and Cortical Bumps: A Continuous Spectrum TD01-TD02
Dr. Asthik Biswas,
78-Omkar Nagar, Arekere Mico Layout, Bannerghatta Road, Bengaluru-560076, Karnataka, India.
Cortical â€˜cleftsâ€™ (schizencephaly) and cortical â€˜bumpsâ€™ (polymicrogyria) are malformations arising due to defects in postmigrational development of neurons. They are frequently encountered together, with schizencephalic clefts being lined by polymicrogyria. We present the case of an eight-year-old boy who presented with seizures. Imaging revealed closed lip schizencephaly, polymicrogyria and a deep â€˜incompleteâ€™ cleft lined by polymicrogyria not communicating with the lateral ventricle. We speculate that hypoperfusion or ischaemic cortical injury during neuronal development may lead to a spectrum of malformations ranging from polymicrogyria to incomplete cortical clefts to schizencephaly.