Single Loading Low Dose MgSo4 Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women QC08-QC12
Dr. Subarna Mitra,
Jainam Planet, Block C, 302,Tatibandh, Raipur-492099, Chhattisgarh, India.
Introduction: Magnesium sulphate is the anticonvulsant of choice in prevention and control of eclamptic convulsions. Pritchardâ€™s regimen is the most popular time-tested regimen used. However, owing to concerns of toxicity, several low dose regimens have been introduced considering the lower body mass index of Asian women.
Aim: To compare the efficacy and safety of a single loading low dose MgSo4 regimen with the Pritchardâ€™s regimen.
Materials and Methods: Seventy cases of eclampsia and imminent eclampsia were allocated to the control and study groups each. The former received the Pritchardâ€™s regimen while the latter was treated with single loading low dose of magnesium sulphate. Recurrent convulsion rates, maternal and perinatal outcomes of both regimens were evaluated and compared using unpaired t-test and Chi-square test for continuous and categorical variables, respectively.
Results: The mean serum magnesium levels were significantly lower in the study group at 30 minutes and 4 hours of initiation of therapy. The single loading low dose regimen was equally efficacious in prevention (96.6% vs 100%, p = 0.934) and control (97.6% vs 97.8%, p = 0.358) of eclamptic fits as compared to the Pritchardâ€™s regimen. The feto-maternal outcomes were also comparable.
Conclusion: The single loading low dose MgSo4 regimen is an effective and safe alternative to the Pritchardâ€™s regimen, especially tailored to the small built Indian women.