Impact of Chronic Kidney Disease on Health-Related Quality of Life: A Prospective Observational Study using the Kdqol-36 Instrument LC66-LC71
Trung Quang Vo,
Department of Pharmacy Administration, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City,
Ho Chi Minh City 700000, Vietnam.
Introduction: Chronic Kidney Disease (CKD) is an umbrella term that describes a wide range of disorders affecting the structure and function of the kidney, seriously devastating the patientsâ€™ health-related quality of life (HRQoL). A great deal of research has been conducted in an attempt to understand the factors that influence HRQoL in CKD patients.
Aim: To identify the HRQoL of patients with CKD in Vietnam and to reveal the association between several socio-demographic factors and the patientsâ€™ HRQoL.
Materials and Methods: The research consisted of a prospective observational study among patients referred to a general hospital for CKD from January to February 2018. The Kidney Disease Quality of Life 36 questionnaire (KDQoL-36) was administered via direct interviews with the patients.
Results: Total 316 participants were recruited, including 194 patients with Stage 5 CKD (61.4%) with an average age of 54.2Â±15.8 years. The mean HRQoL scores of the CKD patients were below average (42.9Â±9.7) with the lowest score in burden of disease domain (21.2Â±17.3). Patients with Stage 1â€“4 CKD scored better than those with Stage 5 CKD in all subscales including Symptom/Problem list (SoD), Burden of Disease (BoD), Physical Component Summary (PCS) (p<0.05), except for Effect of Disease (EoD) and Mental Component Summary (MCS). The multivariable regression analysis results in each HRQoL subscales, exercise and CKD stage were found to be significantly associated with most of the HRQoL indicators in each subscale. CKD stage is predictor of SoD (p<0.001), BoD (p=0.033), PCS (p<0.001), MCS (p=0.015).
Conclusion: The findings illustrate that HRQoL in Vietnamese patients with CKD is below average and there are several socio-demographic characteristics influencing on HRQoL in this population. To improve HRQoL in CKD patients, these socio-demographic factors should be considered by medical researchers and practitioners.