Recovery Profile of Atracurium versus Cisatracurium UC09-UC12
Dr. Joginder Pal Attri,
216, Bhullar Avenue, Fatehgarh Churian Road, Amritsar-143001, Punjab, India.
Introduction: Atracurium and cisatracurium are promising drugs offering a predictable recovery due to non-organ dependent elimination. However, due to the variability in metabolism and narrow therapeutic window, monitoring of neuromuscular functions has significant importance.
Aim: To compare the onset time, duration of block and recovery indices of atracurium and cisatracurium in equipotent doses. The secondary aim included comparing haemodynamic profile and signs of histamine release.
Materials and Methods: The present study was a prospective randomised observational study conducted in the Department of Anaesthesia, Government Medical College, Amritsar, Punjab, India (December 2016 to March 2017). It comprised of 60 ASA Grade I patients in the age group of 18-65 years posted for elective laparoscopic cholecystectomies. Patients were divided into two groups of 30 each. Group C (Cisatracurium) patients received cisatracurium 0.1 mg/kg as loading dose while Group A (Atracurium), patients were administered atracurium 0.5 mg/kg. The onset time, duration of block and recovery index were recorded using Train of Four (TOF) response along with the haemodynamic profile and signs of histamine release, using SPSS 22.0 software considering a p-value<0.05 as significant.
Results: The onset time, duration and recovery index in Group A were found to be 168.60Â±13.44 seconds, 37.12Â±7.62 minutes and 14.63Â±1.84 minutes and in Group C, they were recorded to be 181.03Â±21.76 seconds, 40.37Â±7.04 minutes and 15.30Â±1.96 minutes respectively. The haemodynamic profiles in both the groups were comparable and no signs of histamine release were observed.
Conclusion: Atracurium has a shorter time of onset as compared to cisatracurium in equipotent dose (2xED95) (p-value<0.01). However, the duration of neuromuscular blockade and the recovery profile of both the drugs were comparable.