Serum Nitric Oxide and Plasma HbA1c Levels in Type 2 Diabetes Mellitus Patients BC04-BC06
Shah Yasir Yousuf,
Jawaharlal Nehru Medical College, Belagavi, Karnataka, India.
Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterised by hyperglycaemia and insufficiency of secretion or action of endogenous insulin. Glycated haemoglobin (HbA1c) is commonly used as reliable index to determine cumulative glycaemic history of preceding 2-3 months. Nitric Oxide (NO) is a potent vasodilator and an endothelium-relaxing factor. Low serum Nitric Oxide (NO) levels are known to be associated with endothelial dysfunction in Type 2 Diabetes Mellitus (T2DM).
Aim: To estimate the serum nitric oxide levels in type 2 diabetic patients and correlate it with serum HbA1c levels.
Materials and Methods: The cross-sectional study comprised of 100 (50 male and 50 female) T2DM patients who attended KLEâ€™S Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka, India. Fasting Plasma Glucose (FPG) was measured by Hexokinase method using Roche/Hitachi COBAS 6000 Fully Automated Analyser. HbA1c was estimated using a Bio-Rad D-10 HbA1c program and serum NO was estimated by Classical Griess Reaction. Data was analysed using independent t-test within the groups and Karl Pearson Correlation Coefficient in between the groups. The p<0.05 was considered as statistically significant.
Results: Statistically significant positive correlation was observed between NO and with HbA1c (r=0.7674) and NO with FBS (r=0.5688).
Conclusion: Hyperglycaemia increases NO levels in T2DM patients. Measurement of nitric oxide in early course of diabetes may help in preventing the progression and development of complications like endothelial dysfunction.