Bone Mineral Density among Lean Type II Diabetes Mellitus Patients-A Cross-sectional Comparative Study OC01-OC03
Dr. Deepak Kumar Garg,
2/267, Housing Board Colony, Sawai Madhopur-322021, Rajasthan, India.
Introduction: In case of diabetes mellitus, the pathological process behind fragility of the bone are complex. This process is found to be mediated by various factors like hyperglycaemia, oxidative stress and the accumulation of products of glycation.
Aim: To study bone mineral density in lean diabetics and to compare with normal population.
Materials and Methods: The present study was undertaken as a cross-sectional comparative study among 60 participants (30 cases of lean diabetics and 30 normal controls). The convenient sampling technique was done to select study participants and the study was carried out during the period from January 2015 to December 2016. Patients who were already a known case of Type 2 diabetes mellitus or newly diagnosed to have Type 2 diabetes mellitus whose BMI was <18.5 kg/m2 were considered as cases. Chi-square test was used for finding a statistically significant difference in proportions; Independent student t-test was used for finding the statistically significant difference between means; Pearsonâ€™s correlation coefficient was estimated for finding linear association between two continuous variables; a p-value <0.05 was considered to be statistically significant.
Results: On comparison of cases with controls no statistically significant differences were observed between the two groups in terms of age, waist-hip ratio and BMI (p-value >0.05). Bone mineral density parameters were found to be significantly lower among lean diabetes mellitus patients. HbA1C was found to negatively correlate with that of bone mineral density.
Conclusion: Osteopenia and osteoporosis, characterised by low bone mineral density values were found to be highly prevalent among lean diabetics.