Extra Uterine Leiomyoma with “Amianthoid-like” Fibers ED01-ED02
Dr. Santosh Govind Rathod,
Senior Resident, Department of Pathology, Government Medical College, Aurangabad, Maharastra, India.
Uterine leiomyoma is a benign smooth muscle neoplasm, typically arising in uterus and deep soft tissue. In the present case, tumour size of 7Ă—4Ă—3 cm identified on subserosal aspect of uterus. Grossly, tumour was well circumscribed, whitish nodule and on cut surface whitish whirls were seen. Microscopic examination showed a cellular spindle cell population with numerous eosinophilic amianthoid-like fibers. Immunohistochemically, the tumour showed positivity for H-caldesmon, desmin, alpha smooth-muscle actin, and negativity for CD10. The finding of amianthoid-like fibers in leiomyoma is very rare. Amianthoid fibers are hyalinized collagen mats. It extends the histomorphological spectrum of leiomyomas. Amianthoid fibers are very characteristics of â€śintra nodal palisaded myofibroblastomaâ€ť. Presence of â€śAmianthoid-like fibersâ€ť creates histomorphologically similar picture between leiomyoma and â€śintra nodal palisaded myofibroblastomaâ€ť. Pathologist should be aware of such variant of leiomyoma that contains â€śAmianthoid-like fibersâ€ť to avoid confusion with other tumours.