Unusual Presentation of Primary Ovarian Carcinoid Tumours with Low-to-Moderate Proliferative Potential ED04-ED06
Dr. AK Kapoor,
Pathologist, Department of Pathology, RML Mehrotra Pathology Ltd., Nirala Nagar, Lucknow-226020, Uttar Pradesh, India.
Primary Ovarian Carcinoid Tumour (OCT) are rare benign neuroendocrine neoplasms. Herewith, two cases of ovarian tumour has been described. In case 1, patient was a 63-year-old postmenopausal woman with vague abdominal pain. On examination, she had right pelvic tumour. Right salpingo-oophorectomy was performed. Cut surface showed solid, yellowish-white tumour tissue. Microscopically, tumour showed adenomatous, insular and trabecular patterns. Sheets of tumour cells were separated by fibrovascular septa. Tumour consisted of proliferated epithelial cells showing mild nuclear pleomoprhism. Nucleomegaly and capsular invasion were also seen. Carcinoid tumour cells may convert a silver salt to metallic silver (argentaffin reaction). Imunohistochemical (IHC) staining of tumour revealed strong positivity for pancytokeratin and chromogranin A. Mild reaction with anti-neuron-specific enolase antibody was seen. Ki-67 labelling index of 6% suggested moderate proliferative potential of current tumour. Caudal type home box transcription factor 2 (CDX2) non-reactivity suggested it to be a primary neoplasm. In case 2, the patient was 60-year-old. She had left ovarian tumour. Tumour formed solid masses (insular) and nests forming rosettes. IHC showed strong reactivity with anti-chromogranin A and mild reactivity with anti-neuron-specific enolase. Anti-Ki-67 did not stain most of tumour cells (Ki-67 index 1%). Anti-CDX2 failed to stain tumour cells.