Estimation of Serum Electrolytes and Renal Profile in Hypothyroidism: A Cross-Sectional Study BC17-BC20
Department of Biochemistry, SRM Medical College Hospital and Research Centre,
Kattankulathur, Chennai, Tamil Nadu, India.
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Introduction: Kidneys has important role in the metabolism and removal of thyroid hormones. The water and electrolyte balance in the body was influenced by thyroid hormone. Thyroid dysfunction is usually related with disturbances of calcium and phosphorous homeostasis. It causes significant changes in tubular and glomerular functions of water and electrolyte homeostasis. Both hypothalamus-pituitary-thyroid axis and thyroid hormone peripheral metabolism were affected in Chronic Kidney Disease (CKD).
Aim: To assess the renal parameters and electrolytes in well-defined hypothyroid patients and in age matched apparently healthy controls.
Materials and Methods: The present cross-sectional study was carried in department of endocrinology and internal medicine at SRM Hospital, Tamil Nadu, India from July 2015 to July 2016. A total of 65 aged 35-50 years known hypothyroid patients both males and females were included in this study which forms the study group and 65 age matched controls were also recruited. Serum Urea, Creatinine, Uric acid and electrolytes were estimated by Ion Selective Electrodes (ISE) in the Beckman Coulter (California, USA) AU480 auto analyser. Free Tri iodotyronine (FT3), Free Tyroxine (FT4) and Thyroid Stimulating Hormone (TSH) was done by Fluorometric Enzyme Immunocapture Assay (FEIA) method in TOSOH AIA 360 (Japan) hormone analyser were measured. Estimated Glomerular Filtration (eGFR) was calculated by using MDRD (Modification of diet in renal disease) formula. Statistical analysis was done by using Student t-test and Pearson correlation analysis.
Results: Hypothyroid patients showed significant elevation of serum creatinine, urea and potassium levels (1.39±0.33, 36.7±5.4, 4.78±0.40,p<0.005) when compared to controls. eGFR was decreased significantly in study group (66.8±1.29) when compared to control (96.2±4.69) and (p<0.005).
Conclusion: Hypothyroidism is associated with decreased renal function. Hypothyroid patients should be monitored regularly for renal parameters to prevent chronic kidney diseases.