Evaluation of Hypomagnesemia in Acute Myocardial Infarction Patients OC15-OC16
Dr. Palanichamy Anandan,
Assistant Professor, Department of General Medicine, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
Introduction: Magnesium inhibits potassium efflux and calcium influx, the two events which are harmful to cardiac muscle survival during ischaemia. Magnesium prevents mitochondrial calcium overloading and maintains Adenosine Triphosphate (ATP) synthesis, which could result in smaller infarct size.
Aim: To compare the levels of serum magnesium in patients with Acute Myocardial Infarction (AMI) presenting within the first 24 hours.
Materials and Methods: This case-control study was conducted in Department of Medicine at a Tertiary Care Hospital, for 6 months from June 2018 to December 2018. A total of 60 participants were taken into the study and were divided into two groups. Group-1 was control subjects and Group-2 was patients with AMI. Serum magnesium level was assessed in both the groups and the results were compared. Student’s t-test was performed using SPSS version 21.0.
Results: A total of 73% of patients with AMI were more than 41 years, 53% of patients presented with anterior wall MI, 40% of patients presented with inferior wall Myocardial Infarction (MI) and 7% of patients with anterolateral MI. The mean serum magnesium level in AMI patients was found to be 1.23±0.98 mg/dL and was 2.12±0.68 mg/dL in control group, which was statistically significant.
Conclusion: Low serum magnesium was significantly found in AMI patients and their comorbidities. Therefore supplementation of Magnesium might improve the patients’ outcome.