Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review
Dr. Shaogang Ma,
Department of Endocrinology and Metabolism, Suqian First Hospital, No. 120 Suzhi Road, Suqian City-223800, Jiangsu Province, China.
Klinefelter Syndrome (KS) remains underdiagnosed due to its complex clinical presentation. Here, the authors present the case of a 48-year-old of KS complicated with Type 2 Diabetes Mellitus (DM), hypothyroidism and cryptorchidism as well as perform a literature review. The patient first visited the hospital for diabetes. Male sexual characteristics were missing, complicated with cryptorchidism. Laboratory and chromosome tests were performed to confirm the diagnosis. The patient demonstrated low testosterone and high gonadotropin levels, with the karyotype of 47, XXY. Thus, for diabetes patients who lack male sexual characteristics, gonadal function and chromosome-related examinations should be performed for analysis and differential diagnosis. Based on existing data, there is a pressing need to generate better evidence for KS early diagnosis and comprehensive treatment.