Association of Anti-TPO Antibodies with Insulin Resistance in Patients of Hypothyroidism with Metabolic Syndrome: A Cross-sectional Study BC09-BC13
Dr. Amit Jain,
Senior Resident, Department of Biochemistry, Maulana Azad Medical College, New
Introduction: Hypothyroidism and Metabolic Syndrome (MetS) are associated with insulin resistance. Exact reason for development of insulin resistance in hypothyroidism is still unclear.
Aim: To determine the association between Anti-Thyroid Peroxidase Antibodies (Anti-TPO Abs) and Thyroid Stimulating Hormone (TSH) with components of MetS, Fasting Insulin (FSI) and Homeostatic Model Assessment Index for Insulin Resistance (HOMA-IR).
Materials and Methods: Total 118 subjects of hypothyroidism were included in this cross-sectional study. The diagnosis of MetS was made based on National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Independent association of components of MetS, FSI and HOMA-IR with TSH and anti-TPO Abs was analysed by multivariate linear regression analysis.
Results: MetS was more prevalent in subclinical hyperthyroidism (53.0%) compared to overt hypothyroidism (49.3%). Serum anti-TPO Abs level was significantly high in MetS group compared to non-MetS group in both overt (200.0±170.2 and 122.8±98.9, p=0.02*) and subclinical (184.9±142.9 and 114.5±90.9, p=0.04*) hyperthyroidism. Waist Circumference (WC), Fasting Plasma Glucose (FPG), FSI and HOMA-IR were independently associated with anti-TPO Abs in both overt and subclinical hypothyroidism. Anti-TPO was also increased significantly in linear trend along with increased in the number of MetS components in both overt and subclinical hypothyroidism.
Conclusion: MetS is highly prevalent in hypothyroidism and anti-TPO Abs rather than TSH and is more associated with insulin resistance in patients of hypothyroidism with MetS.