Primary Thyroid Lymphoma in an Adult Male: A Rare Presentation ED07-ED09
Flat 702, Type 5A Building, AIIMS Residential Complex, Kabir Nagar, Raipur, Chhattisgarh, India.
Primary Thyroid Lymphoma (PTL) is a rare entity prevalent in middle to old aged females. They are predominantly B-cell Non-Hodgkin’s Lymphoma (NHL), among which Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype. Here, we describe a case of PTL in a male patient which is extremely rare. He presented with a swelling over anterior aspect of neck and dysphagia since 2 months. Fine Needle Aspiration Cytology (FNAC) of thyroid swelling and following immunocytochemistry showed B-cell NHL. Histopathological and Immunohistochemical (IHC) examination was also done thereafter on right hemithyroidectomy specimen, which revealed a nongerminal center type of DLBCL. Histopathological examination revealed an antecedent chronic lymphocytic thyroiditis in this patient. With this case we noticed that early diagnosis of thyroid lymphoma can be possible with FNAC. However, false negative diagnosis can occur on non-representative aspiration sample. Besides this, it is challenging for a pathologist to subtype the lymphoma on cytology smear. Hence, histopathological examination along with Immunohistochemistry (IHC) is imperative for accurate diagnosis of PTL. The patient had received three cycles of chemotherapy and follow-up of 11 months was uneventful.