High Sensitive C-reactive Protein Level in Relation to Increased Body Mass Index among Non-diabetic Non-hypertensive Women BC17-BC19
Dr. Salah Omar Hussein,
Assistant Professor and Head, Department of Medical Laboratory Science, AL-Ghad International College for Applied Medical Sciences KSA: Al-Madinah Al-Monawarah, KSA, Saudi Arabia.
Introduction: An increased Body Mass Index (BMI) has an adverse effect on the socio-economic and healthcare sectors and may influence metabolic status. High sensitivity C-reactive Protein (hs-CRP) is an emerging biomarker. The association between dyslipidaemia and obesity is well established, and has been found to be the risk factors for CVD.
Aim: To study the relationship of hs-CRP with BMI, lipid profile and magnesium among obese and overweight non-diabetic non-hypertensive Sudanese women.
Materials and Methods: A cross-sectional study was conducted on 90 women in Khartoum state (Sudan), aged between 20 and 43 years, from June to November 2019. The study included three groups of women based on BMI. hs-CRP was measured by using latex immunoturbidimetric method, lipid profile was evaluated using Biosystems colourimetric methods and magnesium by a chemical method. Results were computed using Statistical Package for the Social Sciences (SPSS) version 20.
Results: There was significant increase in the mean values of hs-CRP, Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-C), and a significant decrease in the mean values of High Density Lipoprotein Cholesterol (HDL-C) and magnesium in obese and overweight women, when compared to normal body weight women. Pearson’s correlation coefficient revealed a positive correlation between hs-CRP, and BMI, Waist-To-Hip Ratio (WHR), TC, TG, and LDL-C (p-value <0.01).
Conclusion: Overweight and obese women have increased hs-CRP and atherogenic lipid profile, suggesting obesity to be a state of chronic inflammation. hs-CRP can be used to assess the risk of obesity-related disorders for early intervention.