Pathophysiological Determinants of
Cardiac Remodelling- A Systematic
Review and Meta-analysis
OE01-OE04
Correspondence
Dr. P Bhaskaran,
Hammersmith Hospital, Imperial College, London, United Kingdom.
E-mail: lal@bhask.com
Introduction: Cardiac remodeling is a physiological and pathological condition followed by Myocardial Infarction (MI), valvular dysfunctions and cardiomyopathy. It is associated with cardiac function and structural characteristics. Hence, the remodeling is a therapeutic target following cardiac events.
Aim: This review was conducted to determine the risk of morbidity, mortality and structural characteristics related cardiac remodeling.
Materials and Methods: PubMed, MEDLINE, EMBASE, and ProQuest, were searched electronically, by using {("Morbidity" and "Mortality" and "LV parameters" and "Structural Characteristics") and Cardiac ("Remodeling" and "Regeneration")}. "Mantel-Haenszel Odds Ratio", "mean differences", and "95% Confidence Interval (CI)" were computed for meta-analysis.
Results: Overall, 425 titles or abstracts were identified from the initial search, of which full manuscripts of 103 studies were retrieved. Out of the 103 studies, 22 were subjected to data extraction and analysis. The risk of mortality was higher among patients with myocardial fibrosis. Metoprolol treated group had a lesser incidence of Postoperative Atrial Fibrillation (PAF). Ejection fraction, end systolic and diastolic volumes were consistent between the medical treatments and Percutaneous Coronary Interventions (PCI) groups.
Conclusion: The PCIs are associated with long term survival among the patients with cardiac remodeling.