Histopathological Spectrum of Male Genital System Tumours in a Tertiary Care Hospital Faridkot, Punjab
Dr. Sarita Nibhoria,
Professor and Head, Department of Pathology, Guru Gobind Singh Medical
College and Hospital, Medical Campus, Faridkot-151203, Punjab, India.
Introduction: The male genital system consists of the prostate, seminal vesicle, testes, epididymis, vas deferens, bulbourethral gland, ejaculatory duct, penis and scrotum. Male genital cancers are histologically diverse. They are difficult to detect and treat because of their anatomic locations, biological characters and complications.
Aim: To study the histopathological spectrum of tumours of the male genital system according to World Health Organisation (WHO) classification.
Materials and Methods: The present study is a hospital based descriptive study conducted in the Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India, during February 2019 to August 2020 which included 128 cases. All biopsies, specimens and review blocks and slides of male genital tract tumours were processed and slides were stained with Haematoxylin and Eosin (H&E) stain. Serum tumour markers and immunohistochemical stains were used. The clinical information including symptoms related to the male genital system, histopathological findings and diagnosis were recorded on the predesigned proforma. Other necessary information was collected from the requisition form received along with the biopsy material. The association between categorical variables was explored using Pearsonâ€™s Chi-square test. A p-value <0.05 was considered statistically significant for this study.
Results: The present study included 128 cases, of which the majority of the cases 82 cases (64%) were that of prostate, 28 cases (21.9%) of the penis, 15 cases (11.7%) of testes, two cases (1.6%) were that of the scrotum and one case (0.8%) was of the epididymis. The histopathological spectrum showed adenocarcinoma was present in 80 (62.5%), leiomyosarcoma in 01 (0.8%), lymphoma in 01 (0.8%), mixed germ cell tumour in 9 (7%), seminoma in 5 (3.9%), postpubertal teratoma in 1 (0.8%), basaloid in 1 (0.8%), papillarybasaloid in 2 (1.6%).
Conclusion: Prostate tumours outnumbered all other tumours of the male genital tract with adenocarcinoma of prostate followed by squamous cell carcinoma of the penis and mixed Germ Cell Tumour (GCT) of testes. The present study provides updated information regarding the histopathological spectrum of male genital system tumours.