Biochemical Investigation of Multisystem Inflammatory Syndrome in Children (MIS-C) with SARS-CoV-2 Infection: A Series of seven Cases
Swati Digambar Sawant,
Assistant Professor, Department of Biochemistry, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India.
In children, Coronavirus Disease 2019 (COVID-19) is typically mild. However, in rare cases, children are severely affected, and clinical manifestations are differed from adults. The consequence of COVID-19; Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare complication that seems like toxic shock syndrome or Kawasaki Disease (KD). The MIS-C is characterised by an inflammatory response in the body that occurs four weeks after infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Fever, rashes, diarrhoea, red eyes, and vomiting are common early symptoms that can worsen over time. The inflammation can affect the blood vessels, heart, and other organs, leaving children critically ill and in need of immediate medical attention. Many of the children with MIS-C show positive SARS-CoV-2 serology but negative Polymerase Chain Reaction (PCR), supporting the concept that MIS-C is linked to immunological dysregulation that develops after the acute infection has passed. However, some children do have positive PCR testing. A case series of seven critically ill children with MIS-C in sequential order of admission in the Paediatric Intensive Care Unit (PICU) of tertiary care hospital is illustrated. Key findings of this syndrome include fever, epilepsy, diarrhoea, shock and variable presence of rash. In the present case series, the clinical features, laboratory findings and therapies for a cohort of seven children with MIS-C are presented. Laboratory investigations carried out at early stage of disease can be of vital importance to diagnosis of MIS-C.