Clinical Evaluation of Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease- A Case Series
Dr. Rahul Gupta,
House No.-79/06 Shipra Path, Mansarovar, Jaipur, Rajasthan, India.
In recent years, there has been lot of research on Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) associated disease. It’s clinical phenotype overlaps with Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMOSD), however many questions related to clinical characteristics and pathogenetic role of MOG antibody is still unanswered. Hereby, authors report a case series of nine patients (five females and four males), describing their seropositivity for MOG antibody and clinical characteristics of MOG antibody associated disease. The clinical presentation, radiology, acute treatment and long term management were analysed. The most common presentation was optic neuritis followed by Longitudinally Extensive Transverse Myelitis (LETM). Tab. Azathioprine was most commonly used medicine for disease modifying therapy (long term immunosuppression). The attacks are more severe than MS but recovery is better than antibodies to Aquaporin-4 (AQP4-IgG) seropositive NMOSD.