Russell Body Cervicitis Presenting with Contact Bleeding: A Case Report
Correspondence Address :
Dr. Nandakumar Gopinath,
Professor and Head, Department of Pathology, Government Medical College,
Thiruvananthapuram-695011, Kerala, India.
E-mail: drnandakumar_g@yahoo.co.in
Russell bodies are large (2-3 µm diameter) homogenous hyaline immunoglobulin inclusions, often single, seen in plasma cells displacing the nucleus to a side. When a plasma cell contains multiple vacuoles or inclusions, they are called mott cells. Russell body cervicitis is a rare inflammatory pathology in cervix, characterised by marked infiltration of plasma cells and mott cells. Very little is known about the aetiology, pathogenesis and natural course of this condition. Hereby, authors report an unusual case of a 41-year-old female, who presented with complaints of postcoital bleeding for two weeks. On clinical examination, a small cervical polyp was found and biopsied. Microscopy showed an endocervical polyp with stroma showing dense intense infiltration with plasma cells and multiple mott cells with russell bodies. The cells showed positive immunoreactivity for CD138, kappa and lambda. The histological changes in chronic cervicitis are non specific with a mixed inflammation composed of lymphocytes, plasma cells, histiocytes and stromal fibrosis. However a presentation of sheet like plasmacytic inflammatory infiltrate in the cervix accompanied by numerous russell bodies is a rare histologic finding with very few published literature. A similar histological pattern has been recorded in other sites, including russell body gastritis, a recently recognised pseudotumoral lesion of stomach. Authors have presented this case to contribute to the few articles of russell body cervicitis in literature.
Chronic cervicitis, Mott cells, Plasmacytoma, Plasma cells, Positive immunoreactivity
DOI: 10.7860/JCDR/2021/51030.15769
Date of Submission: Jun 24, 2021
Date of Peer Review: Aug 28, 2021
Date of Acceptance: Sep 30, 2021
Date of Publishing: Dec 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jun 28, 2021
• Manual Googling: Sep 21, 2021
• iThenticate Software: Nov 29, 2021 (1%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com